Au cours de cette présentation, j’exposerai les challenges passé, présent et futur associés à l’obtention d’information structurale sur des macromolécules biologiques. Je me focaliserai sur l’apport des complexes de lanthanide dans la levée de problématiques méthodologiques pour les deux techniques que sont la diffraction des rayons X, en particulier pour la production de cristaux de...
Lanthanide Luminescent Bioprobes (LLBs) exploit the pecular properties of lanthanides such as sharp and intense emission band spread from the visible to the Near Infra-Red (NIR) and long luminescent lifetimes (up to ms for Eu and Tb), which make them useful tools for time-resolved optical imaging. Structurally, LLBs consist in lanthanide chelates functionalized with a chromophore in charge of...
Recent years have seen a renewed interest in circularly polarized luminescence (CPL), the emission asymmetry observed with luminescent chiral molecules. These studies are driven by potential applications, such as bioprobes for microscopy or optimized dyes for current displays, and by the widespread availability of CPL spectrophotometers. While chiral lanthanide(III) complexes are considered...
Les complexes sandwichs divalents volumineux de lanthanides suscitent actuellement un grand intérêt dans le domaine de la recherche scientifique eu égard à leur stabilité, leur réactivité et leurs propriétés physiques incontournables.[1] Les ligands à base de polyarylcyclopentadiényle semblent des candidats très prometteurs dans la synthèse de ce type de structures, en raison de leurs...
Luminescent lanthanide complexes find broad application in UC processes and beyond: in lasers or displays, in solar cells, as anti-counterfeit materials, in photocatalysis and particularly as bioprobes in photodynamic therapy or imaging. Owning the particular nature of the 4f-electrons, the photophysical properties of f-element are uniques (parity-forbidden f-f transition, sharp transition,...
MARS (Multi-Analyses on Radioactive Samples) beamline at the SOLEIL synchrotron is opened to the international community since 2010 and is dedicated to the study of radioactive samples [1] with a specific radioprotection safety design that fulfills the French ASN (Autorité de Sureté Nucléaire) requirements. The beamline is fully devoted to advanced structural and chemical characterizations of...
Electron spin resonance (ESR) spectroscopy is the method of choice for characterizing paramagnetic impurities, with applications ranging from chemistry to quantum computing, but it gives only access to ensemble-averaged quantities due to its limited signal-to-noise ratio. The sensitivity needed to detect single electron spins has been reached so far using spin- dependent photoluminescence,...
